High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche.

After 2 d of HFD, the expressions of Il-7 and Ebf-1, critical to early B-cell development, were down −20% ( P = 0.08) and −11% ( P = 0.06), while Pax-5 expression, a marker indicating an intermediate stage of development, showed only a slight trend in reduction relative to RD (−9%; p = 0.18).

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