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Evaluation of fentanyl disposition and effects in newborn piglets as an experimental model for human neonates.

PLoS One · 2014 · PMC3942469 · PMID 24595018

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an increasing trendno p-value reported
Unlike cardiovascular parameters, which were unmodified except for an increasing trend in heart rate, some of the ventilation and oxygenation indexes as well as brain activity were significantly altered.

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