A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies.

The fact that borderline significance in gene overlap was also observed for categories of disorders sharing clinical risk with MDD (i.e. cardiovascular diseases, inflammation and metabolic syndrome) suggest that the same gene sets may also contribute to dysfunctions in peripheral organs through pleiotropic functions of common genes, hence providing putative biological links for the clinical and symptom co-morbidity.

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