A highly significant source of DA release in the hippocampus derives from the VTA, the dopaminergic neurons of which discharge in response to novel stimuli ( Ljunberg et al. 1992 ; Grenhoff et al. 1993 ) with a phasic burst pattern ( Ljunberg et al. 1992 ).
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Dopamine D1/D5 receptors mediate informational saliency that promotes persistent hippocampal long-term plasticity.
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