Mutations in CG8878, a novel putative protein kinase, enhance P element dependent silencing (PDS) and position effect variegation (PEV) in Drosophila melanogaster.

Of the three alleles tested, only 4a7a, a putative regulatory mutant, males showed a barely significant difference (p = .03) from non-mutant control flies ( CyO balancer) of the same cross indicating that the dominant enhancement (silencing) is dependent upon chromosomal location and not on the w + transgene Pci construct itself ( Figure 4 ).

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