MK-801 Impairs Cognitive Coordination on a Rotating Arena (Carousel) and Contextual Specificity of Hippocampal Immediate-Early Gene Expression in a Rat Model of Psychosis.

Front Behav Neurosci · 2014 · PMC3950493 · PMID 24659959

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0690

boldest claim

The sentences

highly significantp < 10 −6actually significant

Highly significant effects of days ( E : F 2, 56 = 49.4, p < 10 −6 ; MaxT: F 2, 56 = 6.26, p < 0.005; pTime: F 2, 56 = 47.1, p < 10 −6 ; ED: F 2, 56 = 52. 6, p < 10 −6 ) showed robust learning in all rats during training.

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marginally insignificantp < 0.069so close (0.05 < p ≤ 0.1)

Marginally insignificant treatment × session interactions ( E : F 4, 52 = 2.32, p < 0.069; D : F 4, 52 = 2.54, p < 0.051) reflected a trend toward hyperlocomotion and poorer avoidance after the higher dose of MK-801 specifically in session 1.

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fell short of significanceno p-value reported

The t -test analysis fell short of significance, but this shortcoming was partly due to too much impairment rather than too little and partly due to a single animal, which displayed neither deteriorated avoidance nor increased locomotion after switching to 0.15 mg/kg MK-801 and resembled behavioral pattern observed in controls.

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