Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.

Nat Biotechnol · 2014 · PMC3951735 · PMID 24441470

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highly significantno p-value reported

PIQ performs a profile-level significance test for whether or not an estimated TF profile is significant outside its motif match region, and all identified pioneer TFs are highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.