Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.

We investigated whether the genetic variants identified here as associated with ZFP57 expression may be significant in common disease given the many disease associations reported involving the MHC class I region.

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We resolve a highly significant expression quantitative trait locus for ZFP57 involving single-nucleotide polymorphisms (SNPs) in the first intron of the gene co-localizing with a DNase I hypersensitive site and evidence of CTCF recruitment.

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