Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platform.

Interestingly, most intracellular metabolites show constant and similar levels between cultures except for G6P and PEP with an increasing trend after exponential phase ( Figure S10 ).

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While a quasi-constant ratio value is maintained for the parental clone, the low-producer also exhibits a decreasing trend, but to a lower extent than for the high-producer.

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