Androgen effects on skeletal muscle: implications for the development and management of frailty.

Low bioavailable T, but not total T, was related to frailty in cross–sectional analyses in men aged ≥65 years from the Osteoporotic fractures in men study (MrOS), this relationship was marginally nonsignificant in prospective analyses. 73 Lower free and total T were associated with frailty in a sample of 552 Spanish men aged ≥65 years from the Toledo Study for Health and Aging, 74 and in a sample of 54 Taiwanese men recruited from clinical and community settings. 75 In a report from the Concord Health and

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