Probabilistic approach to predicting substrate specificity of methyltransferases.

In the case of yeast MTases, they were highly significant for predicting general substrate specificity (protein, RNA, other), but as expected not significant for predicting more detailed substrate specificity (histone protein, ribosomal protein, other protein, rRNA, tRNA, other RNA, lipid, small molecule, other), where number of categories exceeds the square root of number of known examples, our rule of thumb for maximal number of predictable categories.

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