CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae.

gambiae , CYP6P1 and CYP6P2 were also significant ( Table S2B ), and CYP6P5 only marginally non-significant according to our strict criteria (five out of the six comparisons q<0.05).

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The difference in copy number was highly significant between survivors and dead ( Figure 7B ), with 15/16 survivors but only 5/16 dead females exhibiting a copy number ratio in excess of 1.5 ( Table S5 ), consistent with possession of an additional allele.

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