highly significantp <0.001
In the case of π S , there were highly significant main effects of virus (F 1, 459 = 41.31; p <0.001) and of ORF (F 13, 459 = 14.07; p <0.001), but there was not a significant virus-by-ORF interaction (F 13, 459 = 1.35; n.s.).