Genetic variants of IgG1 antibodies and FcγRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells.

As shown in Table 1 , the inhibitory effect of all 3 genetically disparate IgG1 antibodies on HuHMFG1-dependent NK cell-mediated ADCC against DU145 prostate cancer cells was similar when NK cells expressed the phenylalanine (F)-containing variant of FcγRIIIa, whereas highly significant differences were observed in the presence of NK cells expressing valine (V)-containing FcγRIIIa receptors.

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