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Development of microorganisms for cellulose-biofuel consolidated bioprocessings: metabolic engineers' tricks.

Comput Struct Biotechnol J · 2012 · PMC3962139 · PMID 24688667

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a decreasing trendno p-value reported
However, the cost of added enzyme does not show a decreasing trend over time and still is a major constraint to cost-effective processing of cellulosic biomass [ 6 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.