These findings are highly significant as it suggests that miR-21 dependent regulation of TGFBR2 may be an important mechanism for the prostate tumor cells to proliferate, survive and escape TGFβ1-mediated tumor suppressive effects during early tumor progression.
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Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer.
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