Mutations in PRSS1 put into perspective.

In their article, the authors claim a highly significant association based on a meta-analysis of seven previous case-control studies.

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When data are re-analyzed for the two most commonly examined mutations (N29I and R122H) assuming a dominant mode of inheritance for the minor allele under a random effects model, and applying a Bonferroni correction, the overall net effect remains significant for R122H ( p corrected = .03) but is only borderline significant for N29I ( p corrected = .05, Fig. 1 ).

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