Small dense low-density lipoprotein as a potential risk factor of nephropathy in type 2 diabetes mellitus.

This is in accordance with findings observed by Hirano et al ., who found that LDL particle diameter was significantly smaller in type 2 diabetic patients with nephropathy as compared with in those without nephropathy.[ 22 ] In addition, the current data are in agreement with those in previous studies that documented that all multiple lipoprotein abnormalities described in diabetic patients with nephropathy become more accentuated with increasing urinary albumin excretion.[ 23 24 25 26 ] In addition to highly significant inverse correlation between microalbuminuria and estimated GFR, statistically highly significant inverse correlation between sdLDL and estimated GFR were observed in this study in all patients.

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