Hypoxia induces a HIF-1α dependent signaling cascade to make a complex metabolic switch in SGBS-adipocytes.

With respect to initial GO data suggesting an upregulation of glycogen synthesis, we performed an additional F-match search and identified several highly significant HIF-1α PWMs (−262 to −251 and −162 to −151, and −47 to −34) within the promoter sequence of protein targeting to glycogen (PTG), also known as glycogen synthase 1 (GYS1) activator protein phosphatase 1 regulatory inhibitor subunit 3C (PPP1R3C) and GYS1 ( suppl. 8 ).

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