Effect of maternal steroid on developing diaphragm integrity.

There was no significant difference in MHC IIa transcripts across the different groups ( Figure 3C ), whereas an increasing trend in MHC IIb and MHC IIx transcripts: mRNA expression peaked at 21 d with a 319 and 7.9 fold increase from 2 d to 21 d, respectively ( Figure 3D and 3E ).

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Under control conditions, during 2 d to 21 d postnatal development, we observed a significant MHC fibre transition from MHC neonatal to adult MHC type, particularly increasing fast MHC isoforms and a decreasing trend in key molecules associated with protein synthesis and degradation pathways.

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