In dose-escalation studies, there was an observed trend towards faster clearance at doses less than 1.2 mg/kg/3 weeks (CL=21.1-27.8 mL/d/kg); however, linear PK was observed at higher doses (CL=7.13-12.7 mL/d/kg), indicating a saturable clearance pathway78.
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Mechanistic considerations for the use of monoclonal antibodies for cancer therapy.
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