Barely Significant
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Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.

PLoS One · 2014 · PMC3972236 · PMID 24691516

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a decreasing trendno p-value reported
Three-point bending mechanical tests also showed a significant decrease in Load to Yield (by 30%; p = 0.0091); Yield Stress showed a decreasing trend that was not significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.