extremely significantP <0.0001
P-value (P) >0.05 was considered as not significant (ns), 0.01< P <0.05 as significant and indicated with one asterisks *, 0.001< P <0.01 very significant and indicated with two asterisks **, 0.0001< P <0.001 extremely significant and indicated with three asterisks *** and P <0.0001 extremely significant and indicated with four asterisks ****.