Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.

Although linear peptides can be substrates for recognition by protein domains in, for example, the recognition of phosphotyrosine motifs by SH2 domains and the recognition of RGD motifs by integrins, the mimicking of highly convoluted protein-protein interactions, such as those between CD47 and SIRPα, would be highly significant in terms of targeting this interaction and indeed the large number of other interactions between cell surface proteins.

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