Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage.

In contrast to the observed chemotaxis towards PDGF-BB, IGF-1 and the supernatant of traumatized cartilage, a gradient of IL-1β or TNF-α led to profound and highly significant inhibition of CPC-migration over a broad concentration range (IL-1β from 0.1 to 10 ng/ml, TNF-α from 1 to 100 ng/ml) as shown in Figure 5 .

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