Medial prefrontal cortex: genes linked to bipolar disorder and schizophrenia have altered expression in the highly social maternal phenotype.

It is highly significant in both LS and mPFC arrays, while other glutamate-related genes strongly linked to schizophrenia, such as the kainate receptor 3 ( Grik3 ), and metabotropic glutamate receptors 5 and 7 ( Grm5 , and Grm7 ), are only significant in mPFC (Table 1 ).

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Several genes of interest displayed robust expression changes in the maternal mPFC with borderline significance as reported by microarray analysis, including proenkephalin ( Penk ), and nuclear receptor subfamily 1, group D, member 1 ( Nr1d1 ). qPCR experiments confirmed expression changes for all genes of interest (Figure 2 ) with the following maternal/virgin expression ratios (>1.0 indicating upregulation

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