Early detection of colorectal cancer recurrence in patients undergoing surgery with curative intent: current status and challenges.

In fact, there has been an increasing trend for use adjuvant therapy with local excision, both in the adjuvant and neoadjuvant setting, to downstage the lesions. 37 , 38 Russell and associates reported on 65 patients undergoing local excision followed by either observation or post-operative 5-FU and one of two different radiation therapy doses for high-risk lesions (T 2 , T 3 , positive lymphovascular invasion, size >3 cm or elevated CEA). 39 At a minimum follow-up of 5 years, 11 (17%) patients developed recurrent disease and 8 (12.3%) patients had died.

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