However, Kaplan-Meier analysis showed that higher JARID2 expression was not significantly associated with overall survival (OS) in either fusion gene positive RMS (p=0.386, n=39) or fusion gene negative RMS (p=0.089, n=81), although the latter may be considered a trend towards significance.
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JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.
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