The gastrointestinal tract microbiome and potential link to Alzheimer's disease.

An increased incidence of auto-immunity, exposure to pathogens both pre- and postnatally, and findings of antibodies to brain-specific antigens are common in disorders as diverse as anxiety, autism, depression, obsessive–compulsive disorder, schizophrenia, Parkinson’s disease (PD), and AD, together suggesting that differences in exposure and genetic vulnerability toward HM-mediated auto-immunity may be significant determinants of age-related neurological disease course and outcome as humans age ( 14 , 17 , 23 , 39 , 42 – 46 ); (6) secretory products of the GI-tract microbiome and translocation of these signaling molecules via the lymphatic and systemic circulation throughout the CNS are just beginning to be identified.

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