Advancing personalized care in hemophilia A: ten years' experience with an advanced category antihemophilic factor prepared using a plasma/albumin-free method.

A multivariate analysis adjusted for etiology, site, age, and weight in comparison with ideal weight showed that in both young children and in the older population, time spent with plasma FVIII <1 IU/dL was a highly significant predictor of the rate of all bleeding ( P <0.0001 for young children; P <0.05 for older patients) and the rate of joint bleeds ( P <0.0001 for young children; P <0.02 for older patients).

also in 132,142 other papers

In a multivariate analysis, arthropathy at baseline showed borderline significance ( P =0.072) as a risk factor for increased frequency of joint bleeds, consistent with previous analyses showing that prevention of development of target joints and arthropathy, for example with primary prophylaxis, reduced future bleeding. 6 , 10 , 22 Time of day and time of year were also found to have an association with bleeding.

also in 7,017 other papers