Introduction Genome-wide association studies (GWAS) have revealed a highly significant association between the variation on chromosome 9p21 and the risk of coronary artery disease (CAD) [1] – [4] , which has been validated by studies on different racial and geographic subgroups, independent of traditional risk factors [5] .
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The 9p21 locus is associated with coronary artery disease and cardiovascular events in the presence (but not in the absence) of coronary calcification.
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