Our enzyme kinetic analysis showed that increasing the concentration of the compound led to a dose-dependent decrease of the apparent Michaelis constant (K m ) of the enzyme, while the k cat and k cat /K m values exhibited an initial increasing and then a decreasing trend.
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Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase.
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