Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons.

By contrast, GFP-Simiate and GFP expressing cells exhibited clear distinctions in their surveying activity: While control transfected cells probed their environment with a exploration velocity of 3.1 μm 2 / h ( median + 3.6 μ m 2 / h , − 0.2 μ m 2 / h , Figure 3C ), GFP-Simiate expressing cells achieved only 1.7 μm 2 /h ( median + 0.3 μ m 2 h , − 0.2 μ m 2 / h , Figure 3D ), representing a highly significant reduction ( p < 0.01 , U = 20.00 ).

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