Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

Consistent with FIAU causing a human-specific toxicity, the degree of lactate elevation correlated with the extent of liver humanization (Pearson's correlation: 0.86), and this correlation was highly significant ( p <0.0001) ( Figure 1C ).

also in 132,142 other papers