Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways.

Airway wall circumferential strain, defined as the difference between internal radii at Ptm of 10 and 5 cmH 2 O divided by the radius at Ptm = 5 cmH 2 O at baseline, showed a decreasing trend with time without Ach and without inhibitors (2.6% at T0 vs 2.1% at T90; p = 0.07) but it did not change with Ach, CD or Noc.

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