Cyto-genotoxicity Assessment of Potential Anti-tubercular Drug Candidate Molecule-trans-cyclohexane-1, 4-diamine Derivative-9u in Human Lung Epithelial Cells A549.

Compound “9u” having i-propyl group substitution at p-position was found to be the most potent among all the tested compounds.[ 19 ] In order to evaluate the therapeutic applicability of compound “9u”, showing highly significant activity against M. tuberculosis H 37 Rv stain, toxicity evaluation in the target host cells is also a primary concern.

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