Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model.

This is highly significant considering the fact that the castration-resistant PCa cells are also highly aggressive and more metastatic than their castration-sensitive counterparts ( Jennbacken et al , 2006 ; Srivastava et al , 2012 ).

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