Effect of natural genetic variation on enhancer selection and function.

These experiments identified a combined 82,154 PU.1 and 54,874 C/EBPα peaks, with less than 1% of sites exhibiting highly significant strain-specific binding (PU.1, n=496; C/EBPα, n=263; 4-fold tag count ratio, FDR < 1e −14 , >90% located >3 kb from gene promoters) ( Fig. 1b, c , Extended Data Fig. 1a ).

also in 132,142 other papers