Cyclic nucleotide-gated channels, calmodulin, adenylyl cyclase, and calcium/calmodulin-dependent protein kinase II are required for late, but not early, long-term memory formation in the honeybee.

Acquisition was fast and highly significant ( F (2,294) = 183.65, P < 0.00001), reaching 80% of conditioned responses at the last acquisition trial ( Fig. 1 A).

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The CS response of the saline-injected bees did not differ from that of the SQ 22536-injected bees but was, nevertheless, close to significance ( P = 0.08).

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