Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.

Comparison of performances of gene signatures for survival prediction For all signatures except Hypoxia, differences in DMFS between risk groups were highly significant (n = 912; Figure 1 B).

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We observed borderline significant protective effects (HR < 1: higher risk scores had lower risks for distant metastasis) within the last time interval (>10 years) in the ER-negative group for Intrinsic (p = 0.044), 70-gene (p = 0.007), GGI (p = 0.017) and WR (p = 0.01).

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