highly significantp <0.001
To identify the genomic region(s) mediating HMA, we searched for association between the previously mapped Toxoplasma genetic markers [27] and the HMA phenotype and found a highly significant co-segregation between HMA and chromosome II (LOD ∼6.3; p <0.001, Figure 2C ); only F 1 progeny having type III alleles at chromosome II were HMA + ( Figure S4 ).