As shown, whereas SHR at 15 mo did not further change LW/TL and MFS with respect to 9 mo, SHRF showed a highly significant increase and decrease in these parameters, respectively, as well as changes in left ventricle chamber dimensions at systole (Table S1 in File S1 ).
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Increased Na⁺/Ca²⁺ exchanger expression/activity constitutes a point of inflection in the progression to heart failure of hypertensive rats.
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