HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification.

When we combined the changes in specific epitope-precursor abundances and the favored HIV selection within patients who shared the presenting HLA variant, we found a strong, highly significant host-specific bias toward residues that specifically decrease the yield of epitopes that the host could potentially target ( Table S4 , p < 0.0001 [HIV B] and p = 0.0005 [HIV C], sign test).

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