An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies.

Springerplus · 2013 · PMC4006521 · PMID 24804170

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closest p · 0.0× alpha

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The sentences

highly significantp -value < 0.0001actually significant

This performance is further strengthened by highly significant p -values (2LOmb’s global p -value < 0.0001) and the presence of common SNPs among some or all SNP pairs that are parts of three- and four-locus interactions in the 2LOmb results.

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