European Heart and Rhythm Association guidelines on new oral anticoagulants: A bold step forward.

J Pharmacol Pharmacother · 2014 · PMC4008920 · PMID 24799825

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These aspects are highly significant in renal diseases where strategies have to be worked out for peri-operative renal protection.[ 7 ] In case of renal insufficiency with creatinine clearance (CrCL) <30 the holding time is 36-48 h for Xa inhibitors.

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