TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.

Such studies have yielded highly significant findings showing ERG regulation of pathways that are highly important in PCa, including androgen receptor (AR) pathway, 11 , 12 Wnt/TCF signal transduction, 13 – 15 and polycomb group proteins and cell self-renewal. 11 , 16 While it is clear that these molecular pathways are important mediators of ERG-induced oncogenesis in PCa, very few studies have attempted to examine how ERG might regulate microRNAs, which are increasingly recognized as potent regulators of gene expression and cellular processes.

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