Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.

Transl Psychiatry · 2014 · PMC4012281 · PMID 24690597

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highly significantno p-value reported

We did not find any change in Pde10a, Pde1b or D 2 receptor mRNA levels in the striatum after chronic haloperidol treatment; however, we observed a highly significant increase in the striatal Nts mRNA levels indicating transcriptional activation due to antipsychotic treatment.

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