Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials.

No relation between study size (regression coefficient = −0.109, 95% CI: −0.231, 0.012; P = 0.075, baseline depression severity (regression coefficient = 0.026, 95% CI: −0.007, 0.060; P = 0.116), trial duration (regression coefficient = −0.058, 95% CI: −0.153, 0.038; P = 0.223), age of patients (regression coefficient = 0.013, 95% CI: −0.10, 0.036; P = 0.879), and study quality (regression coefficient = −0.142, 95% CI: −0.357, 0.072; P = 0.183) and omega-3 PUFA efficacy was found, despite study quality almost reached significance when considered only for RCTs conducted on patients with MDD (regression coefficient = −0.403, 95% CI: −0.857, 0.052; P = 0.077).

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