Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.

Mol Oncol · 2014 · PMC4013555 · PMID 24529480

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highly significantno p-value reported

Mutagenesis of these residues leads to a highly significant reduction in LYRIC/AEG‐1 ubiquitination which results in altered sub‐cellular distribution and impairs the interaction between p65, importin‐β and LYRIC/AEG‐1. 2.

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