Another SNP in CHRNA3 , rs938682T/C, showed a marginally significant association for variant genotypes (TC/CC) compared with the wild-type genotype (TT), with an OR = 0.68 (95% CI, 0.45–1.02; p = 0.063) in the dominant model as the fitting model.
Of the five successfully genotyped SNPs, a highly significant association with ADC risk was found for heterozygotes (GA) of rs8042374G/A in the CHRNA3 gene, with an odds ratio (OR) = 1.76 (95% confidence interval (CI), 1.17–2.65; p = 0.024) in the codominant model, as well as a more highly significant association in the overdominant model as the fitting model with an OR = 1.71 (95% CI, 1.15–2.54; p = 0.008) compared with the genotypes (GG/AA) ( Table 2 ).